The progress and challenges of neoantigen-based cancer vaccines
10.13431/j.cnki.immunol.j.20240027
- VernacularTitle:肿瘤新抗原疫苗的研究现状与挑战
- Author:
Ming WU
1
;
Xiaofang XING
;
Gang YAO
Author Information
1. 100085 北京,国家自然科学基金委员会医学科学部;350025 福州,福建医科大学孟超肝胆医院孟超肝胆技术联合创新重点实验室
- Keywords:
Neoantigen;
Cancer vaccine;
Cancer immunology;
Personalized treatment
- From:
Immunological Journal
2024;40(2):195-205
- CountryChina
- Language:Chinese
-
Abstract:
Personalized neoantigen vaccines,a cutting-edge technology in cancer immunotherapy,have garnered significant attention in recent years.Neoantigens are unique antigens produced by tumor-specific mutations,capable of being recognized by the immune system and eliciting a specific anti-tumor immune response.This review summarizes the current state of research on neoantigen vaccines,including the mechanisms of neoantigen generation and relatively screening methods,vaccine design and production,preclinical and clinical research progress,as well as the current challenges and future development trends.We present the potential of neoantigen vaccines in personalized treatment and their significant role in improving the survival rates and quality of life of cancer patients.Additionally,this review highlights the key issues in current research and proposes potential solutions,providing a reference for future studies.
