Detection of chromosomal translocations of DUSP22 and TP63 in ALK?negative anaplastic large cell lymphoma by fluorescence in situ hybridization and related clinical relevance
10.3760/cma.j.issn.0529?5807.2019.10.008
- VernacularTitle:荧光原位杂交检测DUSP22、TP63在间变性淋巴瘤激酶阴性的间变性大细胞淋巴瘤中的染色体易位及其意义
- Author:
Chen WANG
1
;
Xin CHEN
;
Xiaoyan CHEN
;
Yihui HE
Author Information
1. 福建医科大学省立临床医学院福建省立医院病理科
- Keywords:
Lymphoma,T?cell;
Lymphoma,large?cell,anaplastic;
In situ hybridization,fluorescence
- From:
Chinese Journal of Pathology
2019;48(10):791-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To correlate chromosomal translocations of DUSP22 or TP63 with clinical significance in ALK?negative anaplastic large cell lymphoma (ALK-ALCL). Methods Thirty?two patients with ALK－ALCL were selected from January 2004 to January 2014 at Fujian Provincial Hospital for the detection of chromosomal translocations of DUSP22 and TP63 by fluorescence in situ hybridization (FISH). The relationship between DUSP22 and TP63 chromosomal translocations and the clinicopathological parameters of ALK－ALCL was analyzed. Results Among the 32 ALK－ALCL patients, 7(21.8%) had DUSP22 gene rearrangement (DUSP22+ALK－ALCL). Three patients (9.4%) had TP63 gene rearrangement (TP63+ALK－ALCL). There were 22 patients (68.8%) without rearrangement of either DUSP22 or TP63 (DUSP22－TP63－ALK－ALCL). The patients with DUSP22+ALK－ALCL were among the younger, and the patients with TP63+ALK－ALCL were among the elder. The mean age of patients with DUSP22－TP63－ALK－ALCL was between those of DUSP22+ALK－ALCL and TP63+ALK－ALCL (P<0.05). Based on Ann Arbor staging, incidence of DUSP22 gene rearrangement decreased as the clinical stage of ALK－ALCL increased (P<0.05). Incidence of TP63 gene rearrangement cases increases in patients at more advanced clinical stage (P<0.05). The five?year survival rate and prognosis of patients with DUSP22+ALK－ALCL were the highest. Patients with TP63+ALK－ALCL had the lower five?year survival and the worse prognosis (P<0.05). Conclusion Presences of DUSP22 and TP63 chromosomal translocations correlate with the clinical stages and prognosis of ALK－ALCL and may be used for the differential diagnosis, determination of tumor aggressiveness and prognostication of ALK－ALCL.
