Intervention effect of moderate-intensity aerobic exercise on Alzheimer's disease
10.3969/j.issn.1004-1648.2024.05.001
- VernacularTitle:中等强度有氧运动对Alzheimer's病干预效果的分析
- Author:
Qing HE
1
;
Jiebin HAN
;
Peipei WANG
Author Information
1. 221000 徐州医科大学附属徐州市立医院神经内科
- Keywords:
Alzheimer's disease;
aerobic exercise;
cognitive function;
prognosis
- From:
Journal of Clinical Neurology
2024;37(5):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of moderate-intensity aerobic exercise intervention and its influencing factors in patients with Alzheimer's disease(AD).Methods Ninety-eight AD patients were randomly assigned into exercise group(50 cases)and control group(48 cases).The exercise group received moderate-intensity aerobic training for 3 months.Cognitive function was assessed using the MMSE and the AD assessment scale-cognitive subscale(ADAS-cog)at baseline,3 months and 6 months.Daily living abilities was evaluated by the AD cooperative study-activities of daily living scale(ADCS-ADL),behavioral symptoms was assessed by the neuropsychiatric Inventory(NPI)and life quality was measured by quality of life in AD(QOL-AD).The difference between 3 months and baseline ADAS-cog(ADAS-cog3-0)score was used as the dependent variable,multiple-factor linear regression was performed to analyze whether baseline characteristics of patients would affect the efficacy of exercise.Patients with an improvement of ≥4 points in ADAS-cog3-0 were classified into good prognosis group,and the others were classified into non-good prognosis group.Variables with P＜0.05 in the multiple-factor linear regression analysis were included in Logistic regression analysis to determine the best cutoff value through ROC curve.Results Compared with the control group,the exercise group showed a significant increase in MMSE and QOL-AD scores at 3 and 6 months,a significant decrease in ADAS-cog score at 3 and 6 months,a significant increase in ADCS-ADL score at 3 months,and a significant decrease in NPI score at 3 months(all P＜0.05).However,there was no significant difference between the two groups in ADCS-ADL and NPI scores at 6 months.Regression analysis showed that baseline MMSE score had a negative impact on cognitive function improvement in the exercise group,while age,gender,education level,ischemic symptoms,baseline activities of daily living,behavioral and psychological symptoms,and quality of life had no impact.Sensitivity and specificity analysis showed that aerobic exercise was more effective in AD patients with an MMSE score＞21.5 points,and aerobic exercise was still effective but had moderate effects in patients with an MMSE score below this cutoff.Conclusions Aerobic exercise has a significant improvement on cognitive function,activities of daily living,behavioral and psychological symptoms,and quality of life in AD patients.The better the cognitive level is preserved in AD patients,the better the short-term effects of aerobic exercise are.
