Application of esketamine nasal drop in preoperative sedation of children
10.12089/jca.2024.08.016
- VernacularTitle:艾司氯胺酮滴鼻在患儿术前镇静中的应用进展
- Author:
Zhongcheng ZHANG
1
;
Biao LI
;
Maqiang ZHENG
;
Zhicong MA
Author Information
1. 030001 太原市,山西医科大学麻醉学院
- Keywords:
Esketamine;
Nasal drop;
Dexmedetomidine;
Midazolam;
Child;
Sedation
- From:
The Journal of Clinical Anesthesiology
2024;40(8):868-871
- CountryChina
- Language:Chinese
-
Abstract:
As a general anesthetic,esketamine has the advantages of sedation,analgesia,and slight respiratory depression within the clinical dose range,which is suitable for preoperative sedation in children.Intravenous injection is mostly used in clinical practice,but nasal dropping is not affected by the venous access and has a rapid onset time with no first pass effect.The recommended nasal dose of esket-amine is 1 mg/kg,with reliable sedation effect and few adverse reactions.When combined with dexmedeto-midine or midazolam,sedation onset time of esketamine can be significantly shortened,the respective drug dosage can be reduced,and postoperative pain can be alleviated.Nasal dropping alone or combined with dexmedetomidine can be safely used in children with congenital heart disease complicated by pulmonary hy-pertension,which helps to maintain the stability of hemodynamic.This article summarizes the current situa-tion of clinical application of nasal dropping of esketamine to provide reference for its rational application.
