Research progress on the correlation between norepinephrine and systemic immune inflammation in-dex
- VernacularTitle:去甲肾上腺素与系统性免疫炎症指数相关性的研究进展
- Author:
Jiayin LIN
1
;
Chunsheng WANG
;
Jianrong YE
Author Information
- Keywords: Systemic immune inflammation index; Norepinephrine; Perioperative period; Progno-sis; Inflammatory response; β2 adrenergic receptors
- From: The Journal of Clinical Anesthesiology 2024;40(8):860-864
- CountryChina
- Language:Chinese
- Abstract: Perioperative management and protection are inextricably linked to the occurrence of postoperative complications.Higher levels of postoperative inflammation are associated with increased post-operative complications and mortality.Systemic immune-inflammation index(SII)is a newly proposed sys-temic immune inflammatory response marker,which can better respond to the level of inflammation,and maintaining a low level of SII during surgery can greatly reduce the occurrence of postoperative complica-tions,promote disease recovery,and reduce mortality.Norepinephrine(NE)has the function of inhibiting inflammatory response,inhibiting the synthesis and release of pro-inflammatory factors through β2-adrenergic receptors,and promoting the secretion of anti-inflammatory factor IL-10.Therefore,this review e-laborates on the mechanism of action of norepinephrine and the relationship between NE and systemic SII levels,and further explores the effect of norepinephrine on SII by regulating inflammatory cells.
