Immunohistochemical evaluation of mutant p53 protein over-expression in non-mucinous adenocarcinoma in-situ and invasive adenocarcinoma, Immunohistochemical evaluation of mutant p53 protein over-expression in non-mucinous adenocarcinoma in-situ and invasive adenocarcinoma, NOS of lung
10.3760/cma.j.issn.0529-5807.2015.03.005
- VernacularTitle:肺非黏液型原位腺癌与非特殊型浸润性腺癌中突变 p53蛋白过表达的意义
- Author:
Yayan CUI
1
;
Jie ZHANG
;
Jiping DA
;
Honglei ZHANG
;
Dong CHEN
Author Information
1. 100029,首都医科大学附属北京安贞医院病理科
- Keywords:
Lung neoplasms;
Adenocarcinoma;
Tumor suppressor protein p53;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2015;(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the over-expression of mutant p53 protein in non-mucinous adenocarcinoma in-situ ( NMAIS ) and invasive adenocarcinoma, NOS of lung. Methods Immunohistochemical study for p53 protein was performed on 17 cases of NMAIS and 70 cases of invasive adenocarcinoma, NOS of lung.The difference in p53 over-expression between the two tumor subtypes was analyzed.Results The over-expression of mutant p53 protein was observed in 0 case (0%) of NMAIS and 37 cases (52.9%) of invasive adenocarcinoma, NOS of lung.The difference was of statistical significance (P =0.000).Conclusion Mutant p53 protein over-expression may play a role in the progression of NMAIS to invasive adenocarcinoma, NOS.
