Research progress of cannabinoid type 1 receptors involved in pain modulation mechanism
- VernacularTitle:大麻素1型受体参与疼痛调节机制的研究进展
- Author:
Ting ZHOU
1
;
Wenjuan LI
;
Rongxin LIU
;
Jie ZHANG
;
Jianjun XUE
Author Information
- Keywords: Cannabinoid type 1 receptor; Pain; Analgesic mechanism; Endogenous cannabinoid
- From: The Journal of Clinical Anesthesiology 2024;40(6):648-651
- CountryChina
- Language:Chinese
- Abstract: Cannabinoid type 1 receptor(CB1R)is one of the most widely studied endocannabinoid receptors in recent years,which is expressed in both central and peripheral nerve systems.CBIR is located in the presynaptic membrane,and regulates the release of neurotransmitters through retrograde inhibitory synaptic transmission,which is an effective target for the treatment of pain.Activation of CB1R has analgesic effect on injurious,pathological,and inflammatory pain,and antagonism of CB1R can cause pain sensitization.This article describes CB1R from the aspects of structure and function,signal transduction,and analgesic mechanism,so as to provide reference for further understanding the pathophysiology of pain and exploring better pain treatment methods.
