Expression of mitogen-activated protein kinase in prostatic intraepithelial neoplasia
10.3969/j.issn.1001-1420.2001.06.014
- VernacularTitle:MAPK在前列腺上皮内瘤中的表达及其意义
- Author:
Yucheng LI
1
;
Shumin ZHANG
;
Tienan BAI
;
Tengxiang MA
Author Information
1. the Second Hospital Tianjin Medical University
- From:
Journal of Clinical Urology
2001;16(6):273-274
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of mitogen-activated protein kinases (MAPKs) and explore whether MAPKs play an important role in the tissue of prostatic intraepithelial neoplasia (PIN).Methods:In this study,samples of 12 cases with PIN and 16 cases with benign prostate hyperplasia (BPH) were examined using immunohistochemical staining with ERK1/2 antisera.Results:A variety of levels of immunohitochemical staining for MAPK have been detected in all of 12 cases with PIN.An increased expression of MAPK in cytoplasm has been noted in 6 of 12 cases with PIN.Compared with BPH,activaty of MAPK increased 1.48 fold in PIN (P＜0.05.Conclusions:There is a higher levels of MAPK activaty in PIN than in BPH. MAPK might be a major pathway of transducing prostatic neoplasia signals, and has promotive effect on the progression of prostatic neoplasia.
