Study on the correlation between bladder cancer and T/NT (Radioactivity ratio of target over nontarget)in introvesical radioimmunoimaging
10.3969/j.issn.1001-1420.2001.06.002
- VernacularTitle:放射免疫显像中T/NT与膀胱癌的相关性研究
- Author:
Yifeng GUO
1
;
Lizhang YU
;
Chunli ZHANG
;
Bainian PAN
;
Zhilian MIN
Author Information
1. Changzheng Hospital of Second Military Medical University
- From:
Journal of Clinical Urology
2001;16(6):245-247
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To evaluate the correlation between bladder cancer and T/NT (Radioactivity ratio of target over nontarget) in introvesical radioimmunoimaging with 99m Tc-BDI-1 in bladder cancer.Methods:In 38 cases with bladder cancer and 8 cases without bladder cancer, radioimmunoimaging was performed 1hr after intravesical administration of 111～222 MBq 99m Tc-BDI-1 followed by washing out and perfusing bladder with 50 ml PBS. Radioactivity radio of target over nontarget (T/NT) was calculated.Results:By virtue of the criteria of T/NT value (≥1.40),there was not only the high sensitivity (91.4%) and the high specificity (87.5%) of diagnosis, but also no difference between small tumors (＜1 cm) and big ones (≥1 cm) in sensitivity in introvesical radioimmunoimaging. T/NT was related to the grade, the stage and the morphology of the tumor. It was possible to determine positive correlation between T/NT and the grade and stage of the transitional cell carcinoma of the bladder.Conclusions:In intravesical radioimmunoimaging T/NT value provided a new means for determining the extent of malignant bladder tumor. It may be useful for the early diagnosis, the choice of treatment and evaluation of prognosis in bladder cancer.
