Research progress of reversing treatment resistance in head and neck squamous cell carcinoma by targeting lipid metabolism
10.13591/j.cnki.kqyx.2024.09.011
- VernacularTitle:靶向脂代谢逆转头颈鳞癌治疗耐药性的研究进展
- Author:
Pan WANG
1
;
Jiong LYU
;
Huiyong ZHU
Author Information
1. 浙江大学医学院附属第一医院口腔颌面外科,浙江杭州(310000);浙江大学医学院,浙江杭州(310000)
- Keywords:
lipid metabolism;
head and neck squamous cell carcinoma;
treatment resistance;
cancer therapy
- From:
STOMATOLOGY
2024;44(9):705-709
- CountryChina
- Language:Chinese
-
Abstract:
The reprogramming of lipid metabolism is a significant factor influencing various aspects of head and neck squamous cell carcinoma,including its occurrence,development,metastasis,and resistance to radio-chemotherapy.There is a considerable elevation in the expression levels of enzymes and genes related to lipid metabolism in tumor tissues compared to normal tissues.This up-regulation is associated with both treatment resistance and a poor prognosis.This review focuses mainly on alterations in lipid metabolism in head and neck squamous cell carcinoma.It systematically explores the atypical expression and clinical significance of lipid metabolism-related enzymes,evaluates their influence on treatment resistance,elucidates the underlying mechanisms of this resistance,and discus-ses current and potential targeted therapeutic approaches.The comprehensive analysis comprises four pivotal aspects:de novo lipogene-sis,fatty acid oxidation,glycerophospholipids metabolism,and mevalonate and cholesterol synthesis pathways.Feasible strategies,such as the adjustment of dietary structure,the administration of multi-target drugs,and the utilization of combination treatment thera-pies,are deliberated as potential interventions to modulate lipid metabolism,reverse treatment resistance,and enhance the efficacy of anti-cancer treatments.
