Different types of programmed cell death in periodontitis
10.13591/j.cnki.kqyx.2024.08.012
- VernacularTitle:不同类型程序性细胞死亡在牙周炎中的研究进展
- Author:
Shasha ZHU
1
;
Weidong TIAN
;
Shujuan GUO
Author Information
1. 口腔再生医学国家地方联合工程实验室,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医(学)院,四川成都(610041)
- Keywords:
periodontitis;
programmed cell death;
apoptosis;
autophagy;
pyroptosis
- From:
STOMATOLOGY
2024;44(8):624-629
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis is a chronic inflammatory and destructive disease in which plaque acts as an initiator.Recruitment of host im-mune cells and production of multiple inflammatory mediators leads to periodontal tissue damage.Programmed cell death(PCD)is a self-destructive process that is actively initiated by cells under specific conditions and can be mainly categorized into apoptosis,necrop-tosis,autophagy,pyroptosis,ferroptosis,cuproptosis,etc.Different types of programmed cell death have their own distinctive roles in periodontitis.In this review,we summarizes the characteristics of different types of PCD and their role in the progression of periodonti-tis,in order to provide new research ideas on the pathogenic mechanism of periodontitis and more references for the precise treatment of periodontitis.
