Research progress of TACAN's involvement in orthodontic mechanical pain modulation

VernacularTitle:TACAN参与正畸机械性疼痛调控的研究进展
Author: Siyi XU ¹ ; Zhenze YANG ; Leilei XUE ; Yezi QI ; Jun LIN
Author Information

1. 浙江大学医学院附属第一医院口腔正畸科,浙江杭州(310000)
Keywords: TACAN; oral mechanical pain; ion channel
From: STOMATOLOGY 2024;44(7):540-544
CountryChina
Language:Chinese
Abstract: Orthodontic treatment mainly improves oral function and achieves treatment goals by applying mechanical force to the jaw-bone and teeth.However,oral pain is the most common symptom experienced by patients during the diagnosis and treatment process.It is usually caused by sustained application of orthodontic mechanical force,but its mechanism is not fully understood,posing a signifi-cant clinical challenge.In recent years,a protein called TACAN has been discovered to play a crucial regulatory role in the occurrence and development of pain,offering a potential therapeutic target for addressing mechanical pain in the future.Since research on TACAN is still unclear,its specific mechanism requires further elucidation and verification.This article systematically reviews the research pro-gress of TACAN's involvement in the modulation of mechanical pain,summarizes the specific functions of TACAN,and provides new perspectives for further research on TACAN.