Glycated haemoglobin A1c predicts the mortality risk in patients with influenza pneumonia
10.3760/cma.j.issn.1671-0282.2024.06.013
- VernacularTitle:糖化血红蛋白预测流感肺炎患者死亡风险
- Author:
Fei TENG
1
;
Ziyi LI
;
Haiyang ZHAO
;
Daorong LI
;
Xinhua HE
Author Information
1. 首都医科大学附属北京朝阳医院急诊医学中心，心肺脑复苏北京市重点实验室，北京 100020
- Keywords:
Influenza;
Pneumonia;
Glycated hemoglobin A1c;
Mortality risk;
Survival analysis
- From:
Chinese Journal of Emergency Medicine
2024;33(6):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether glycated haemoglobin A1c (HbA1c) can be used as a predictor of mortality risk in patients with influenza pneumonia.Methods:This study was a single-center retrospective study, and enrolled patients with influenza pneumonia in the Emergency Department and in-patient departments of Beijing Chaoyang Hospital, Capital Medical University from 2017 to 2019. Gender, age, underlying diseases, influenza virus nucleic acid or antigen results, chest X-ray or chest CT reports, routine blood test, biochemical indicators, HbA1c and procalcitonin (PCT) were collected, and all subjects were divided into survival and death groups based on 28-day mortality. The differences between the two groups were compared and Cox regression was used to analyze risk factors for 28-day mortality.Results:In this study, 122 patients with influenza pneumonia were included, and 94 (77.0%) cases were divided into the survival group and 28 (23.0%) cases into the death group. Univariate analysis showed that lymphocyte counts [0.49 (0.33, 0.73) vs. 0.77 (0.49, 1.23) ×10 9/L, Z= -3.008, P=0.003] were lower and HbA1c levels [6.5 (6.1, 7.1) vs. 6.1 (5.7, 6.8) %, Z= 2.203, P= 0.028] and PCT levels [0.64 (0.20, 6.43) vs. 0.16 (0.05, 0.87) μg/L, Z=2.594, P=0.009] were higher in dead patients compared with those in the survivors. Cox multivariate regression and survival analysis found that after adjusting for age, lymphocyte counts ( HR=0.260, 95% CI: 0.087-0.773, P=0.015) and HbA1c levels ( HR=1.295, 95% CI:1.007-1.666, P=0.044) were independent risk factors for 28-day mortality. Conclusions:HbA1c is an independent risk factor for predicting 28-day mortality in patients with influenza pneumonia.
