The differences in the growth of transplanted hepatocellular carcinoma and the efficacy of TACE in experimental rats with different liver backgrounds
10.3969/j.issn.1008-794X.2024.10.010
- VernacularTitle:不同肝背景下大鼠移植性肝癌肿瘤生长及TACE治疗疗效的差异
- Author:
Hang ZHAO
1
;
Xiaolei SONG
;
Xuan ZHENG
;
Yujie ZHANG
;
Jun ZHOU
Author Information
1. 266000 山东青岛 山东大学齐鲁医院(青岛)介入科
- Keywords:
hepatic artery chemoembolization;
liver cancer;
fatty liver;
cirrhosis;
difference in efficacy;
CD34
- From:
Journal of Interventional Radiology
2024;33(10):1095-1100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the difference of various indicators in the growth of transplanted liver cancer in experimental rats with the background of normal liver,fatty liver and liver cirrhosis,and to discuss the difference in the curative effect after TACE.Methods Walker-256 ascites tumor cells were implanted into the rats with normal liver,fatty liver,and cirrhosis liver separately to establish the experimental liver cancer models.TACE treatment was performed for all experimental rats.All the indicators related to tumor growth and the curative effect of TACE were compared among the three groups of rats with different liver backgrounds.Results In terms of the liver volume,there were differences among the three groups,but the differences were not statistically significant(P＞0.05).No statistically significant differences in the preoperative liver functions existed among the three groups,but some indicators of postoperative liver functions in the fatty liver group were significantly higher than those in the cirrhosis group,and the differences were statistically significant(P＜0.05).No significant differences in microvessel density were observed among the three groups(P＞0.05).However,in the same group statistically significant differences in the above indexes existed between the preoperative values and the preoperative ones(P＜0.05).Conclusion The results of this study indicate that during the growing period of tumor the following three changes can be observed:① There are differences in tumor volume.Cirrhosis may inhibit tumor growth in the early stage,but in the later stage the cachexia of cirrhosis rats may accelerate tumor growth;② There were no significant differences in liver functions between fatty liver and cirrhosis;and ③ There was no significant difference in microvessel density among the rats with different liver backgrounds.However,with the tumor growing,the microvessel density will be slightly increased.After TACE treatment the following three changes can be observed:① There is no significant difference in tumor volume;② Fatty liver rats have more liver function reserve capacity when compared with cirrhotic rats;③ There is no obvious change in microvessel density,although the embolization treatment can stimulate the proliferation of the microvessel.
