Medical glue versus embolization microspheres for interventional embolization of massive hemoptysis:a comparative analysis of the clinical effects
10.3969/j.issn.1008-794X.2024.08.006
- VernacularTitle:医用胶与栓塞微球介入栓塞治疗大咯血临床效果对比分析
- Author:
Liping JIANG
1
;
Qibin WANG
Author Information
1. 832000 新疆石河子 石河子大学第一附属医院介入诊断治疗科
- Keywords:
hemoptysis;
bronchial artery;
medical glue;
embolization microsphere;
interventional embolization
- From:
Journal of Interventional Radiology
2024;33(8):844-848
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effectiveness and safety of medical glue and embolization microspheres in the vascular interventional treatment for patients with massive hemoptysis.Methods The clinical data of 77 patients with massive hemoptysis,who were admitted to the First Affiliated Hospital of Shihezi University of China between May 2019 and April 2023 to receive medical glue treatment or embolization microspheres treatment as the medication therapy was not effective,were retrospectively analyzed.According to the embolization materials used,the patients were divided into medical glue group(n=39)and microspheres group(n=38).The hemostatic efficacy,adverse reactions,cost of embolization materials,success rate of vascular embolization,and vascular recanalization were compared between the two groups.Results In the medical glue group and microspheres group,significant hemostatic effect was seen in 27 patients(69.2％)and 22 patients(57.9％)respectively,effective hemostatic effect in 9 patients(23.1％)and 10 patients(26.3％)respectively,and invalid hemostatic effect in 3 patients(7.7％)and 6 patients(15.8％)respectively;the total effective rate was 92.3％and 84.2％respectively,the difference was not statistically significant(P=0.461).In the medical glue group and microspheres group,postoperative chest and back pain was seen in 8 patients(20.5％)and 3 patients(7.9％)respectively,chest tightness in 2 patients(5.1％)and 4 patients(13.2％)respectively,subcutaneous hematoma in one patient(2.6％)and zero patient(0.0％)respectively,and aphasia in zero patient(0.0％)and one patient(2.6％)respectively;all the above symptoms were relieved after symptomatic treatment in all patients;no statistically significant difference in the incidence of adverse reactions existed between the two groups(P=0.234).The average cost of embolization materials used during operation in the medical glue group and microspheres group was(8605.7.3±4077.8)Chinese yuan and(10414.5±3571.2)Chinese yuan respectively,the difference was statistically significant(P=0.014).In medical glue group,a total of 204 responsible vessels were successfully obstructed,with a technical success rate of 100％,which was higher than 90.8％(121/133)in microspheres group,and the difference was statistically significant(P＜0.01).The incidence of recurrent hemoptysis in medical glue group occurred was 7.7％(n=3),which was lower than 28.9％(n=11)in microspheres group,and the difference was statistically significant(P＜0.01).In the medical glue group no recanalization of the embolized blood vessels was observed,while in the microspheres group the recanalization rate of the embolized blood vessels was 9.1％(11/121),and the difference was statistically significant(P＜0.01).Conclusion For the treatment of patients with massive hemoptysis,interventional embolization therapy,regardless of using medical glue as embolization agent or using microspheres as embolization agent,is clinically safe and effective.Compared with the microspheres,the medical glue carries a higher success rate of vascular embolization,while its recurrence rate of hemoptysis,vascular recanalization rate and amount of embolization materials used during surgery are remarkably lower,which has certain advantages in the interventional therapy of massive hemoptysis,and it is worthy of clinical promotion and application.
