Lauromacrogol combined with different concentrations of pingyangmycin for low-flow venous malformations of limbs:analysis of therapeutic effect
10.3969/j.issn.1008-794X.2024.05.004
- VernacularTitle:聚桂醇联合不同浓度平阳霉素介入治疗肢体低流速静脉畸形的疗效
- Author:
Meng WANG
1
;
Xiaofeng CHEN
;
Qiang ZHANG
;
Xiaoqi HE
;
Ning HAN
;
Ye YANG
Author Information
1. 710002 陕西西安 西安儿童医院胸外科/肿瘤(血管瘤)介入中心
- Keywords:
venous malformations;
interventional therapy;
intravascular sclerotherapy
- From:
Journal of Interventional Radiology
2024;33(5):483-487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effect of lauromacrogol combined with different concentrations of pingyangmycin in the treatment of low-flow venous malformations of limbs.Methods A total of 83 child patients with low-flow venous malformations of limb,who were admitted to the Xi'an Thoracic Surgery/Tumor(Hemangioma)Intervention Center of China between 1 January 2021 and 1 June 2022,were enrolled in this study.The child patients were randomly divided into group A(n=42)and group B(n=41).Under imaging guidance,lauromacrogol mixed together with pingyangmycin(2 mg/mL in group A,and 1 mg/mL in group B)was slowly injected into the cavity of venous malformations until the drug mixture filled the tumor cavity.The curative effect,number of treatments within 6 months,and the incidence of adverse reactions were compared between the two groups.Results Successful interventional sclerotherapy was accomplished in all the 83 child patients of both groups.During the follow-up period of 6 months,the effective rate in group A and group B was 92.9％(39/42)and 87.8％(36/41)respectively.A total of 88 interventional procedures were performed in group A and 137 interventional procedures in group B,the difference between the two groups was statistically significant(x2=3.282,P=0.047).Adverse reactions occurred in 10 child patients of group A and in 8 child patients of group B,the difference between the two groups was not statistically significant(P=0.709).Conclusion In treating low-flow venous malformations of limbs,the use of higher concentration pingyangmycin and lauromacrogol mixture has quite the same curative effect and incidence of adverse effects as the use of lower concentration pingyangmycin and lauromacrogol mixture,although the use of higher concentration pingyangmycin and lauromacrogol mixture can reduce the number of treatments in child patients.(J Intervent Radiol,2024,33:483-487)
