Current progress on the role of central nervous system boarder-associated macrophages in brain homeostasis and diseases
10.16098/j.issn.0529-1356.2024.04.004
- VernacularTitle:中枢神经系统边界相关巨噬细胞在大脑稳态和脑疾病中作用的研究进展
- Author:
Chen-Shuo SHAO
1
;
Li-Hang WEI
;
Guo-He TAN
Author Information
1. 广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心;广西医科大学长寿与老年相关疾病教育部重点实验室,南宁 530021
- Keywords:
Central nervous system;
Boarder-associated macrophage;
Cerebrospinal fluid circulation;
Homeostasis regulation;
Central nervous system diseases
- From:
Acta Anatomica Sinica
2024;55(4):399-406
- CountryChina
- Language:Chinese
-
Abstract:
An increasing number of studies have been focused on the field of immune system in the central nervous system(CNS),as the viewpoint of CNS immune privilege being challenged.Among them,CNS boarder-associated macrophages(BAMs)play a prominent role in the regulation of brain homeostasis and related diseases.Unlike microglia located in the brain parenchyma,BAMs are a type of specialized macrophages located in the meninges(including dura,arachnoid,and leptomeninges),perivascular spaces,and choroid plexus.They are crucial for immune surveillance,cerebrospinal fluid drainage,antigen clearance,material exchange,and etc.Here,we reviewed a series of relevant studies on the origin and roles of BAMs in CNS,so as to broaden the understanding of the mechanisms of by which BAMs maintain the brain homeostasis,as well as provide novel insights into the treatment of CNS diseases including Alzheimer's disease.
