Research progress of neoantigens in tumor immunotherapy
10.11855/j.issn.0577-7402.1340.2024.0426
- VernacularTitle:肿瘤新抗原在肿瘤免疫治疗中的应用研究进展
- Author:
Jing-Song CHEN
1
;
Dan WANG
Author Information
1. 西安医学院第二附属医院科研科,陕西 西安 710038
- Keywords:
neoantigen;
tumor;
immunotherapy;
clinical trial
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(10):1213-1220
- CountryChina
- Language:Chinese
-
Abstract:
Tumor neoantigens are antigens encoded by tumor-specific mutated genes,characterized by high specificity,significant exogenous origin,mutation randomness,clonal distribution and correlation with gene mutation.Because these antigens are not negatively screened by the thymus and recognized by T cells as"heterogeneous".They are less easily affected by the immune tolerance mechanism and exhibit strong immunogenicity,making them excellent targets for immunotherapy.Tumor neoantigens can be used to develop therapeutic vaccines,induce and cultivate T cells with stronger targeting capabilities,and are promising for predicting tumor survival prognosis and responses to immune checkpoint blockade therapies.This review summarizes the recent advances in clinical application of tumor neoantigen-based immunotherapy,and prospects for future research directions.
