Research progress on the mechanism of non-coding RNA regulation of hemophilia A
10.11855/j.issn.0577-7402.1014.2023.1220
- VernacularTitle:非编码RNA对血友病A的调控机制研究进展
- Author:
Hui ZHANG
1
;
Hong-Yi LI
;
Zi-Ning WANG
;
Xue-Chun LU
Author Information
1. 山西医科大学医学科学院,山西 太原 030001
- Keywords:
hemophilia;
coagulation factors;
miRNA;
gene regulation
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(10):1196-1200
- CountryChina
- Language:Chinese
-
Abstract:
Hemophilia,which includes different types such as hemophilia A and hemophilia B,is a hemorrhagic disorder with inherited blood clotting abnormalities.The main clinical manifestations are spontaneous bleeding of joints,muscles and deep tissues or repeated bleeding after trauma.It often starts at an early age and affects the whole life.The treatment of hemophilia patients is still dominated by alternative therapy,supplementing the corresponding clotting factors.In addition,non-factor drug therapy is adopted such as bispecific monoclonal antibodies and gene therapy.In recent years,the research on the pathogenesis of hemophilia A has made great progress,which is no longer limited to the mutation of the coding sequence of coagulation factor gene as the only cause of hemophilia.Many studies have found that abnormal expression of non-coding RNA(ncRNA)is involved in the regulation of coagulation factor Ⅷ(FⅧ)mRNA and protein,which not only explains why patients with normal FⅧ genotypes still present with hemophilia A,but also provides new directions for understanding the pathogenesis of other types of hemophilia.This paper reviews the research progress on the regulatory mechanism of ncRNA in hemophilia A.
