Protective effect of remazolam on important organs
10.11855/j.issn.0577-7402.0981.2023.1220
- VernacularTitle:瑞马唑仑对重要器官的保护作用
- Author:
Sen LI
1
;
Jin-Xin LAN
;
Duo YANG
;
Jun-Bing HE
;
Long-Sheng ZHANG
Author Information
1. 广东医科大学第一临床医学院,广东 湛江 524023;揭阳市人民医院麻醉科,广东 揭阳 522000
- Keywords:
remazolam;
organ protection;
organ damage;
inflammation response
- From:
Medical Journal of Chinese People's Liberation Army
2024;49(10):1105-1109
- CountryChina
- Language:Chinese
-
Abstract:
Remazolam is a γ-aminobutyric acid(GABA)receptor agonist.It is a short-acting benzodiazepine drug that has just been launched in China in recent years.Its mechanism of action is to enhance inhibitory neurotransmitters of GABA in the central nervous system.It has been widely used in clinical practice for sedation,hypnosis,anti anxiety,and the treatment of insomnia.Meanwhile,remazolam is mainly used for induction and maintenance of general anesthesia during the perioperative period,with a fast onset time and a brief duration of action.Recent studies have shown that remazolam can protect important organs and alleviate organ damage by reducing inflammatory responses and oxidative stress,regulating cell apoptosis,and other pathways.This article summarizes the protective effects and mechanisms of remazolam on the brain,heart,liver,and lung,providing a theoretical basis for the clinical application of remazolam.
