The role of CD109 antigen in glioma
10.16352/j.issn.1001-6325.2024.12.1731
- VernacularTitle:CD109抗原在胶质瘤中的作用
- Author:
Pinghui ZHOU
1
;
Sijie CAO
;
Dong YUE
;
Fengyun DONG
Author Information
1. 济宁医学院 临床医学院,山东 济宁 272067
- Keywords:
CD109;
glioma;
drug resistance;
recurrence
- From:
Basic & Clinical Medicine
2024;44(12):1731-1735
- CountryChina
- Language:Chinese
-
Abstract:
Leukocyte differentiation antigen CD109(CD109)is a glycosylphosphatidylinositol(GPI)-associated cell surface antigen,belonging to the α-2 macroglobulin/C3,C4 and C5 super family complex,and is a transfor-ming growth factor(TGF)-β/Smads co-receptor.CD109 regulates the occurrence and development of glioma and is closely related to drug resistance and recurrence of glioma.As a cell membrane protein,CD109 can be directly la-beled by specific antibodies or enzymes,and may also be recognized by targeted vectors for drug delivery,which is expected to become an effective diagnostic molecular marker and pharmacological therapeutic target.
