Advances in metabolic remodeling of glutamine in pancreatic cancer
10.16352/j.issn.1001-6325.2024.11.1613
- VernacularTitle:胰腺癌中谷氨酰胺代谢重构的研究进展
- Author:
Ke LIU
1
;
Menghua DAI
Author Information
1. 中国医学科学院 北京协和医学院 临床医学专业试点班,北京 100730;中国医学科学院 北京协和医学院 北京协和医院 基本外科,北京 100730
- Keywords:
glutamine;
glutaminolysis;
pancreatic cancer;
cancer metabolism;
combination therapy
- From:
Basic & Clinical Medicine
2024;44(11):1613-1617
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer relies on glutamine(Gln)in its carcinogenesis.Gln metabolism is reprogrammed by multiple oncogenes and their downstream effectors in pancreatic cancer cells.The Gln dependence and its underlying molecular mechanisms can potentially be exploited as therapeutic targets.Recent research on the meta-bolic remodeling of Gln in pancreatic cancer has primarily focused on the inhibition of key enzymes,the impact on chemotherapy resistance,and the application of Gln antagonists.The progress in understanding Gln metabolism in pancreatic cancer offers valuable insights into potential novel therapeutic strategies.
