Preclinical translational research and application of tumor organoids
10.16352/j.issn.1001-6325.2024.09.1214
- VernacularTitle:肿瘤类器官临床前转化研究及应用
- Author:
Yujia XIA
1
;
Zhenli YANG
;
Yuqin LIU
Author Information
1. 中国医学科学院基础医学研究所 北京协和医学院基础学院 病理学系,北京 100005
- Keywords:
tumor organoid;
precise treatment;
organoid biobank
- From:
Basic & Clinical Medicine
2024;44(9):1214-1218
- CountryChina
- Language:Chinese
-
Abstract:
More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied.This model is able to reproduce the genomic,transcriptome,proteome and other omics features of pa-rental tumors without heterogeneity found in cell line models.Based on these characteristics,tumor organoids have gradually become a representative preclinical model,facilitating the translation of new research results and precision treatment of patients.This article summarizes the latest progress of tumor organoids on R&D of technology and appli-cation,focusing on the current methods of establishing tumor organoids,opportunities and challenges in clinical and research application.
