Research progress on the type 1 diabetes induced sarcopenia
10.16352/j.issn.1001-6325.2024.08.1189
- VernacularTitle:1型糖尿病诱发肌少症的研究进展
- Author:
Qingyi PENG
1
;
Lingling XU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院 内分泌科,北京 100730
- Keywords:
type 1 diabetes mellitus;
sarcopenia;
epidemiological;
pathogenesis;
treatment
- From:
Basic & Clinical Medicine
2024;44(8):1189-1193
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of sarcopenia in type 1 diabetes is higher than that in type 2 diabetes and non-diabetes patients.Screening,diagnosis and intervention of sarcopenia in type 1 diabetes patients as early as possible is of great significance for improving the life quality of these patients.The occurrence of sarcopenia in type 1 diabetes mellitus may be closely related to the decline of skeletal muscle function caused by the decrease of insulin-like growth factor-1,activation of inflammatory factors,mitochondrial dysfunction,and accumulation of advanced glyca-tion end-products.At present,the mechanism of the occurrence and development of sarcopenia induced by type 1 diabetes is not completely clear,and the relevant new drug treatment lacks data support.Further in-depth research may bring a new direction for the prevention and treatment of sarcopenia in type 1 diabetes patients.
