Progress on the role of MBD2 pathway in severe asthma
10.16352/j.issn.1001-6325.2024.08.1165
- VernacularTitle:MBD2通路在重症哮喘中作用的研究进展
- Author:
Dingjiang WU
1
;
Xiufeng ZHANG
Author Information
1. 海南医学院第二附属医院呼吸内科,海南海口 570216
- Keywords:
severe asthma;
methyl-CpG binding domain protein 2(MBD2);
T helper 17 cells
- From:
Basic & Clinical Medicine
2024;44(8):1165-1169
- CountryChina
- Language:Chinese
-
Abstract:
Severe asthma is a chronic inflammatory disease that is not sensitive to glucocorticoid treatment.In the pathogenesis of severe asthma,T helper cell 17(Th 17)and interleukin 17(IL-17)play an important role,mainly by aggregating the infiltration of neutrophil to aggravate the severity of asthma.Methyl-CpG-binding protein 2(MBD2)plays an important role in the differentiation of Th 17 cells from naive CD4+T cells,positively regulate Th17 differentiation and IL-17 expression.MBD2 binds to the CpG islands in the promoter region of interferon regu-latory factor 4(IRF4),suppressor of cytokine signaling 3(S0CS3),hypoxia-inducible factor-1α(HIF-1α)and misshapen like kinase 1(MINK1),which leads to methylation,regulates the differentiation of Th 17 cells,and par-ticipates in the pathogenesis of severe asthma.
