Comparison of adverse reactions and effects of IMRT combined with different chemotherapy regimens in patients with early stage esophageal squamous cell carcinoma
10.16352/j.issn.1001-6325.2024.07.1018
- VernacularTitle:IMRT联合不同化疗方案在早期食管鳞癌患者中不良反应及疗效的比较
- Author:
Wei ZHANG
1
;
Zhen ZHANG
;
Dong LIU
;
Houzhou JIANG
;
Wei LIANG
Author Information
1. 太和县人民医院 肿瘤放疗科,安徽 阜阳 236000
- Keywords:
esophageal squamous cell carcinoma;
distant metastasis;
adverse reaction;
short-term and long-term effect;
concurrent chemoradiotherapy
- From:
Basic & Clinical Medicine
2024;44(7):1018-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adverse reactions,short-term and long-term effects of DP(docetaxel+cis-platin)regimen and PF(cisplatin+5-fluorouracil)regimen combined with intensity modulated radiation therapy(IMRT)in patients with distant metastatic esophageal squamous carcinoma.Methods From January 2021 to June 2022,96 patients with non-metastatic esophageal squamous carcinoma were randomly divided into 48 cases in Taihe County People's Hospital of Fuyang City,Anhui province and 48 cases in control group.Which was treated with DP plus IMRT.The observation group was treated with PF plus IMRT.The occurrence of adverse reactions and the effect of both groups were compared.Results Compared with control group,the difference in the incidence of adverse re-action was not significant.The total effective rate was higher in the observation group than in that in control group(83.3%vs 62.5%,P＜0.05).Overall survival,1-year survival,3-year survival in observation and in control group were 70.83%vs 50.00%,79.36%vs 60.23%and 65.10%vs 35.52%.Long-term outcomes were observed and compared.The median survival time was 34.40 months in the observation group and 18.3 months in control group(P＜0.05).Conclusions DP regimen combined with IMRT is more effective than PF regimen combined with IMRT in the treatment of patients with distant metastatic esophageal squamous carcinoma.
