The CXCL10/CXCR3 axis in acute respiratory distress syndrome
10.16352/j.issn.1001-6325.2024.06.0892
- VernacularTitle:CXCL10/CXCR3轴在急性呼吸窘迫综合征中的作用
- Author:
Qi SHENG
1
;
Jin TONG
Author Information
1. 重庆医科大学附属第二医院 呼吸与危重症医学科,重庆 400010
- Keywords:
CXCL10/CXCR3 axis;
acute respiratory distress syndrome;
inflammations;
pulmonary embolism;
pulmonary fibrosis
- From:
Basic & Clinical Medicine
2024;44(6):892-896
- CountryChina
- Language:Chinese
-
Abstract:
The CXC chemokine ligand-10/CXC receptor-3(CXCL10/CXCR3)axis,a crucial pathway mediating Th1-type immunity,substantially contributes to the development of acute respiratory distress syndrome(ARDS)by enhancing inflammatory storms.It additionally promotes vascular endothelial apoptosis and impedes vasculature re-pair,elevating the risk of pulmonary vascular thrombosis.Conversely,this axis plays a protective role in limiting extra-cellular matrix deposition and modulating cell migration,thereby mitigating pulmonary fibrosis.The various mechanisms of the CXCL10/CXCR3 axis in the pathogenesis and progression of ARDS could offer novel insights for the diagnosis and treatment of ARDS.
