Risk factors of primary Sj?gren's syndrome combined with osteoporosis

VernacularTitle:原发性干燥综合征合并骨质疏松的危险因素
Author: Wuxinrui HUANG ¹ ; Jing TIAN ; Jieyu HE
Author Information

1. 中南大学湘雅二医院风湿免疫科,长沙 410011
Keywords: primary Sj?gren's syndrome; osteoporosis; risk factors
From: Journal of Central South University(Medical Sciences) 2024;49(2):312-318
CountryChina
Language:Chinese
Abstract: Primary Sj?gren's syndrome(pSS)is a systemic autoimmune disease that is prevalent in middle-aged and elderly women,characterized by dry mouth,dry eyes,fatigue,and joint pain.Nearly one-third pSS patients have been suffering with osteoporosis(OP),displaying symptoms of lumbago,back pain,and even fracture,all of which severely affect their life quality.Common risk factors for pSS and OP include gender and age,persistent state of inflammation,immune disorders,intestinal flora imbalance,vitamin D deficiency,dyslipidemia and sarcopenia.Meanwhile,the comorbidities of pSS,such as renal tubular acidosis,primary biliary cholangitis,autoimmune thyroid diseases,and drugs(glucocorticoids,methotrexate,and cyclophosphamide)are unique risk factors for pSS complicated with OP.Education,guidance of healthy lifestyle,and OP screening are recommended for bone management of pSS patients.Early detection and intervention are crucial for keeping bone health and life quality in pSS patients.