Clinical Observation on Short-Term Efficacy of Huoxue Xiaozhong Powder for the Treatment of Mild-to-Moderate Knee Osteoarthritis of Qi Stagnation and Blood Stasis Syndrome
10.13359/j.cnki.gzxbtcm.2024.11.019
- VernacularTitle:活血消肿散治疗轻中度气滞血瘀证膝骨关节炎的短期临床疗效观察
- Author:
Jing ZHAO
1
;
Du-Jun MA
;
Hou-Jun ZHU
;
Yu-Jie BI
;
Yu-Xin YANG
Author Information
1. 广州中医药大学第四临床医学院,广东 深圳 518033
- Keywords:
knee osteoarthritis;
qi stagnation and blood stasis;
Huoxue Xiaozhong Powder;
Shuangbai San;
erythrocyte sedimentation rate;
C-reactive protein;
synovial thickness
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(11):2948-2953
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term efficacy of Huoxue Xiaozhong Powder(i.e.,Shuangbai San)for the treatment of patients with mild-to-moderate knee osteoarthritis(KOA)of qi stagnation and blood stasis syndrome.Methods Sixty patients with mild-to-moderate KOA of qi stagnation and blood stasis syndrome were randomly divided into the treatment group and the control group,with 30 cases in each group.The treatment group was treated with external application of Huoxue Xiaozhong Powder,and the control group was treated with external application of Voltaren(diclofenac diethylamide emulsion).Both groups were treated for one week as a course.The changes of visual analogue scale(VAS)score,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score and erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)level and synovial thickness under ultrasound in the two groups before and after treatment were observed.Moreover,the clinical efficacy and safety of the two groups were evaluated.Results(1)After one week of treatment,the total effective rate of the treatment group was 93.33%(28/30),and that of the control group was 73.33%(22/30).The intergroup comparison(tested by rank sum test)showed that the clinical efficacy of the treatment group was significantly superior to that of the control group(P＜0.05).(2)After treatment,the VAS score,WOMAC score,ESR,CRP level and synovial thickness under ultrasound in the two groups were significantly improved compared with those before treatment(P＜0.01),and the treatment group had stronger effect on the improvement of VAS score,WOMAC score,ESR,CRP level and synovial thickness under ultrasound than the control group(P＜0.01).(3)During treatment,no obvious adverse reactions such as skin redness,swelling and itching occurred in the two groups of patients,which had a high safety.Conclusion For the patients with mild-to-moderate KOA of qi stagnation and blood stasis syndrome,the use of Huoxue Xiaozhong Powder for external treatment alone can also achieve good short-term clinical effects,which can effectively alleviate the symptoms of pain,and reduce the levels of inflammatory indicators and synovial thickness.
