Forty Years for Lung Cancer Research:the Construction of the Phlegm-Toxin Theory and the Application of Qi-Replenishing and Phlegm-Removing Method
10.13359/j.cnki.gzxbtcm.2024.10.014
- VernacularTitle:肺癌研究40年:痰毒理论的构建与益气除痰法的应用
- Author:
Li-Zhu LIN
1
;
Ling-Ling SUN
;
Xiang-Jun QI
Author Information
1. 广州中医药大学第一附属医院肿瘤中心,广东省中医临床研究院,广东广州 510405
- Keywords:
lung cancer;
qi deficiency of lung and spleen;
phlegm-toxin;
replenishing qi and removing phlegm;
survival;
quality of life;
anti-tumor mechanism;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(10):2601-2607
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer has the highest morbidity and mortality in China.Guiding by Chinese medical master ZHOU Dai-Han and based on the experience of diagnosis and treatment of lung cancer in the past 40 years,the authors believe that phlegm is the key to the pathogenesis of lung cancer,and then put forward the phlegm-toxin pathogenesis theory according to the clinical characteristics of lung cancer.Lung cancer is a disease of deficiency in origin and excess in superficiality.Qi deficiency of lung and spleen leads to the formation of phlegm-toxin,and phlegm-toxin is the key pathogenic factor for the development and progression of lung cancer.Based on the phlegm-toxin pathogenesis,the treatment of lung cancer with the method of replenishing qi and removing phlegm(abbreviated as Yiqi Chutan method)is proposed.The clinical practice of the research team in recent years has shown that Yiqi Chutan method is effective in the treatment of middle-to-advanced lung cancer,in particular the middle-to-advanced lung cancer in the elderly,which can prolong the survival time of patients with advanced lung cancer,improve the quality of life of lung cancer patients,relieve lung cancer related symptoms,enhance the efficacy and reduce the toxicity of anti-tumor treatment,and prevent and treat early lung cancer.The study on the anti-tumor mechanism of Yiqi Chutan method showed that the anti-tumor mechanism of Yiqi Chutan Formula was related to the inhibition metastasis of lung cancer,regulation of cell cycle,inhibition of epithelial-mesenchymal transition,regulation of the apoptosis and autophagy of cells,and improvement of the EGFR-TKIs resistance.
