Research Progress of Chinese Herbal Medicine in Intervening Premature Ovarian Failure by Regulating PI3K-AKT Signaling Pathway
10.13359/j.cnki.gzxbtcm.2024.09.041
- VernacularTitle:中药通过调控PI3K-AKT信号通路干预卵巢早衰的研究进展
- Author:
Yong-Han ZHAO
1
;
Hong-Li MA
;
Xin-Ming YANG
Author Information
1. 黑龙江中医药大学研究生院,黑龙江哈尔滨 150040
- Keywords:
premature ovarian failure;
Chinese herbal medicine;
PI3K/AKT signaling pathway;
inflammatory response;
apoptosis;
autophagy;
oxidative stress;
cell proliferation;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(9):2508-2514
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,a large amount of studies have confirmed that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway plays a decisive role in the follicular atresia and apoptosis by regulating the inflammatory response,apoptosis and autophagy,and oxidative stress of ovarian cells as well as ovarian granular cell proliferation,which is a key pathway for the occurrence and development of premature ovarian failure(POF).Traditional Chinese medicine(TCM)has obvious advantages in the treatment of chronic complex diseases such as POF,and the regulation of PI3K/AKT signaling pathway is one of the mechanisms of the prevention and treatment of POF with Chinese herbal medicine.The intervention of POF with TCM can be achieved by inhibiting the inflammatory response,counteracting oxidative stress,inhibiting apoptosis and autophagy,and promoting granular cell proliferation in the occurrence and development of POF through the regulation of the PI3K/AKT signaling pathway.This article reviewed the role of PI3K/AKT signaling pathway and its upstream and downstream molecules in the pathogenesis of POF,and explored the mechanism of TCM in intervening POF through the PI3K/AKT signaling pathway,which will provide theoretical evidence for the basic research and new drug development for POF.
