Research Progress in the Pharmacological Actions and Mechanism of Kidney-Supplementing Prescriptions for the Treatment of Male Reproductive Function Decline Caused by Kidney Deficiency
10.13359/j.cnki.gzxbtcm.2024.09.040
- VernacularTitle:补肾方药治疗肾虚所致男性生殖功能衰减的药效和机制研究进展
- Author:
Lu-Na ZHANG
1
;
Di-Xin CHEN
;
Qi-Peng WANG
;
Zi-Lun PENG
;
Yong-Jun LIU
;
Yan-Fen CHEN
;
Dan JIA
Author Information
1. 广东药科大学,广东广州 510006;广州医药研究总院有限公司,广东广州 510240
- Keywords:
kidney-supplementing prescriptions;
male reproductive function decline;
hypothalamic-pituitary-gonadal axis;
oxygen free radicals;
blood-testis barrier;
spermatogenic cell apoptosis;
Wuzi Yanzong Pills;
Shenqi Pills;
Yougui Pills;
Liuwei Dihuang Pills;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(9):2499-2508
- CountryChina
- Language:Chinese
-
Abstract:
The current situation of childrearing in the elderly and low birth rate showed that the prevention and treatment of infertility risk caused by the decline of male reproductive function are increasingly becoming prominent.The decline of male reproductive function is closely related to the hypothalamic-pituitary-gonadal axis,oxygen free radicals,blood-testis barrier,and the apoptosis of spermatogenic cells.Traditional Chinese medicine believes that the kidney stores essence and is in charge of reproduction,and the decline of reproductive function is closely related to the imbalance of yin and yang of the kidney.Therefore,kidney-supplementing method is helpful for treating the decline of reproductive function caused by kidney deficiency.Kidney-supplementing prescriptions were effective on systematically regulating the function of the hypothalamic-pituitary-gonadal axis,thus to significantly delay the decline of reproductive function,were effective on removing excessive oxygen free radicals in the body and protecting cells from oxidative damage,and were effective on improving spermatogenesis by restoring the blood-testis barrier and regulating the apoptosis of spermatogenic cells.The representative kidney-supplementing prescriptions for improving the decline of reproductive function caused by kidney deficiency include Wuzi Yanzong Pills,Shenqi Pills,Yougui Pills,Liuwei Dihuang Pills,Zuogui Pills and Guilu Erxian Soft Extract.The above formulas presented no single therapeutic mechanism but multiple-way,multiple-level and multiple-target mechanism,and the formulas can comprehensively regulate the internal environment of the body,so as to achieve the purpose of improving male reproductive function.The kidney-supplementing therapy of traditional Chinese medicine plays an irreplaceable role in the treatment of male reproductive function decline.The in-depth study of its therapeutic mechanism will provide guide for clinical practice and will supply theoretical basis for improving male reproductive function decline.
