Clinical Study on Oral Administration of Guizhi Decoction Combined with Acupoint Application of Banxia Fuling Decoction in Treating Hyperemesis Gravidarum of Taiyin Syndrome Type
10.13359/j.cnki.gzxbtcm.2024.08.016
- VernacularTitle:桂枝汤内服联合半夏茯苓汤穴位贴敷治疗太阴证型妊娠恶阻的临床研究
- Author:
Hui ZHOU
1
;
Fan-Wei WU
;
Zi-Qi LIN
Author Information
1. 广州中医药大学第七临床医学院,广东深圳 518000;广州中医药大学附属宝安中医院,广东深圳 518000
- Keywords:
nausea and vomiting of pregnancy;
hyperemesis gravidarum;
Guizhi Decoction;
Banxia Fuling Decoction;
acupoint application;
clinical efficacy;
quality of life;
the negative conversion rate of urinary ketone bodies
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(8):2047-2054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of oral administration of Guizhi Decoction combined with acupoint application of Banxia Fuling Decoction in the treatment of hyperemesis gravidarum(nausea and vomiting during pregnancy)of taiyin syndrome.Methods Sixty patients with hyperemesis gravidarum of taiyin syndrome were randomly divided into the treatment group and thecontrol group at the ratio of 1∶1,with 30 cases in each group.The control group was given acupoint application of Banxia Fuling Decoction on the acupoints of Zhongwan(CV12),bilateral Neiguan(PC6),bilateral Zusanli(ST36),and bilateral Yinlingquan(SP9).The treatment group was treated with Guizhi Decoction orally on the basis of treatment for the control group.Both groups were treated for 2 weeks.The changes of Pregnancy-Unique Quantification of Emesis(PUQE)score,Nausea and Vomiting of Pregnancy Specific Quality of Life Questionnaire(NVPPQOL)score and traditional Chinese medicine(TCM)syndrome score in the two groups were observed before and after treatment.Multiple linear regression analysis was performed for the exploration of the influencing factors of PUQE score in the two groups before treatment.After treatment,the cured and markedly effective rate,negative conversion rate of pregnancy anxiety and negative conversion rate of urinary ketone bodies were compared between the two groups.Results(1)After 2 weeks of treatment,the cured and markedly effective rate of the treatment group was 86.67%(26/30),and that of the control group was 56.67%(17/30).The intergroup comparison showed that the cured and markedly effective rate of the treatment group was significantly superior to that of the control group(P＜0.05).(2)After treatment,the PUQE score,NVPPQOL score and TCM syndrome score of the two groups were significantly decreased compared with those before treatment(P＜0.05),and the decrease of PUQE score,NVPPQOL score and TCM syndrome score in the treatment group was significantly superior to that in the control group(P＜0.05).(3)Pearson correlation analysis showed that PUQE score was negatively correlated with gestational age(P＜0.05),but had no correlation with gestational weeks and anxiety score(P＞0.05).(4)After treatment,the negative conversion rate of pregnancy anxiety in the treatment group was 16.67%(5/30),and that in the control group was 6.67%(2/30).There was no significant difference between the two groups(P＞0.05).(5)After treatment,the negative conversion rate of urinary ketone bodies in the treatment group was 53.33%(16/30),and that in the control group was 13.33%(4/30).The intergroup comparison showed that the negative conversion rate of urinary ketone bodies in the treatment group was significantly higher than that in the control group(P＜0.01).(6)There were no obvious adverse reactions or adverse events in the two groups during the treatment,and there were no abnormal changes in the blood and urine routine test,liver and kidney function indicators and other safety indexes of the patients,with high safety.Conclusion Oral administration of Guizhi Decoction combined with acupoint application of Banxia Fuling Decoction can effectively alleviate the symptoms of nausea and vomiting,improve the quality of life of patients,and increase the negative conversion rate of urinary ketone bodies in the patients with hyperemesis gravidarum of taiyin syndrome.Moreover,there is a certain correlation of the nausea and vomiting PUQE score with the age of the patients.
