Clinical Efficacy of Liuwei Anshen Capsules Combined with Amlodipine Plus Benazepril in the Treatment of Senile Essential Hypertension Patients Complicated with Anxiety and Depressive Disorders and Its Intervention Effect on NR2B Protein Expression
10.13359/j.cnki.gzxbtcm.2024.08.009
- VernacularTitle:六味安神胶囊联合氨氯地平贝那普利治疗老年原发性高血压伴焦虑抑郁障碍患者的临床疗效及对NR2B蛋白表达的干预作用
- Author:
Hui-Qiong LI
1
;
Sheng-Jun MA
;
Xun-Ping MA
;
Li LIU
;
Dan LIU
Author Information
1. 湖北省国药葛洲坝中心医院,湖北宜昌 443000
- Keywords:
Liuwei Anshen Capsules;
Amlodipine+Benazepril Tablets;
senile essential hypertension;
anxiety and depressive disorders;
accumulation of excess phlegm-heat;
N-methyl-D-aspartate receptor 2B subunit(NR2B)protein
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(8):2001-2008
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Liuwei Anshen Capsules combined with Amlodipine+Benazepril Tablets in the treatment of senile essential hypertension(EH)patients complicated with anxiety and depressive disorders and its intervention effect on the expression of N-methyl-D-aspartate receptor 2B subunit(NR2B)protein.Methods A retrospective study was conducted on 138 senile EH patients complicated with anxiety and depressive disorders of accumulation of excess phlegm-heat syndrome treated in the Geriatric Department of Sinopharm Gezhouba Central Hospital from December 2020 to December 2022.The patients were divided into an observation group and a control group according to the treatment schemes,with 69 cases in each group.The control group was treated with Amlodipine+Benazepril Tablets and routine psychotherapy,and the observation group was treated with Liuwei Anshen Capsules orally on the basis of treatment for the control group.The course of treatment lasted for one month.The changes of blood pressure indicators of systolic blood pressure(SBP)and diastolic blood pressure(DBP),Hamilton Anxiety Scale(HAMA)score,17-Item Hamilton Depression Scale(HAMD-17)score,NR2B protein expression,and the levels of monoamine neurotransmitters of dopamine(DA),epinephrine(NE),and 5-hydroxytryptamine(5-HT)in the two groups were observed before and after treatment.After treatment,the clinical efficacy and total incidence of adverse reactions were compared between the two groups.Results(1)After one month of treatment,the total effective rate of the observation group was 95.65%(66/69),and that of the control group was 75.36%(52/69).The intergroup comparison(tested by chi-square test)showed that the curative effect of the observation group was significantly superior to that of the control group(P＜0.01).(2)After treatment,the SBP and DBP of the two groups were significantly decreased compared with those before treatment(P＜0.05),and the decrease of SBP and DBP in the observation group was significantly superior to that in the control group(P＜0.01).(3)After treatment,the HAMA score and HAMD-17 score of the two groups were significantly decreased compared with those before treatment(P＜0.05),and the decrease of HAMA score and HAMD-17 score in the observation group was significantly superior to that in the control group(P＜0.01).(4)After treatment,the expression level of NR2B protein in the two groups was significantly decreased compared with that before treatment(P＜0.05),and the decrease in the observation group was superior to that in the control group(P＜0.01).(5)After treatment,the levels of serum DA,NE and 5-HT in the two groups were significantly decreased in comparison with those before treatment(P＜0.05),and the decrease of serum DA,NE and 5-HT levels in the observation group was significantly superior to that in the control group(P＜0.01).(6)The total incidence of adverse reactions in the observation group was 2.90%(2/69)and that in the control group was 5.80%(4/69).There was no significant difference between the two groups(P＞0.05).Conclusion Liuwei Anshen Capsules combined with Amlodipine+Benazepril Tablets can effectively alleviate the bad mood,decrease blood pressure,inhibit the overexpression of NR2B protein,and correct the disorder of monoamine neurotransmitters in senile EH patients complicated with anxiety and depressive disorders of accumulation of excess phlegm-heat syndrome.The combined treatment does not cause serious adverse reactions,which is safe and effective.
