Research Progress in Traditional Chinese Medicine Syndromes in Animal Models of Depression After Ischemic Stroke
10.13359/j.cnki.gzxbtcm.2024.07.040
- VernacularTitle:缺血性卒中后抑郁动物模型中医病证研究进展
- Author:
Jie-Ying HE
1
;
Yue YANG
;
Liang-Ying LIAO
Author Information
1. 湖南中医药大学第一附属医院,湖南长沙 410007
- Keywords:
post-ischemic stroke depression;
animal models;
disease-syndrome combination in traditional Chinese medicine;
liver-qi stagnation syndrome;
qi deficiency and blood stasis syndrome;
phlegm clouding mental orifice syndrome;
kidney deficiency syndrome;
review
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(7):1926-1930
- CountryChina
- Language:Chinese
-
Abstract:
Post-ischemic stroke depression(PISD)is a common complication of cerebrovascular disease.This article reviewed the research progress in the modeling methods and model evaluation of PISD in China in recent years,and the research progress in modeling methods for disease-syndrome combined animal model of PISD in traditional Chinese medicine(TCM),in order to provide a basis for expanding the clinical application of TCM therapy and carrying out the research on the therapeutic mechanism.The PISD model was mostly established by the method for stroke model combined with the modeling method for depression syndrome.The combined methods included the method of internal carotid artery suture-occlusion and ligation combined with chronic unpredictable mild stress(CUMS)and feeding alone,method of suture-occlusion and ligation of left internal carotid artery,right external internal carotid artery,and bilateral vertebral artery combined with feeding alone and restraint stress,and the method of suture-occlusion and ligation of unilateral common carotid artery combined with predictable stress and feeding alone.The disease-syndrome combined animal model of PISD in TCM involved the replication of liver qi stagnation syndrome,qi deficiency and blood stasis syndrome,phlegm clouding mental orifice syndrome,and kidney deficiency syndrome.Till now,the established disease-syndrome combined animal model of PISD in TCM only has the pathological manifestations of western medicine and the symptom characteristics of TCM syndromes,whether the model presenting the essence of disease-syndrome combination in clinical patients remains to be studied.
