Efficacy and Safety of Therapy of Tonifying Kidney and Promoting Blood Circulation Combined with Cyclosporine Plus Androgen for the Treatment of Aplastic Anemia:A Meta-Analysis
10.13359/j.cnki.gzxbtcm.2024.07.039
- VernacularTitle:补肾活血法联合环孢素及雄激素治疗再生障碍性贫血的有效性及安全性的Meta分析
- Author:
Zhi-Jing HU
1
;
Xiao-Min ZHANG
;
Hui-Xuan LAN
;
Jie WU
;
Ling-Ling ZHU
Author Information
1. 南方医科大学中西医结合医院血液肿瘤科,广东广州 510315;南方医科大学中医药学院,广东广州 510515
- Keywords:
aplastic anemia;
therapy of tonifying kidney and promoting blood circulation(Bushen Huoxue method);
cyclosporine;
androgen;
clinical efficacy;
safety;
meta-analysis
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(7):1919-1926
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the clinical efficacy and safety of therapy of tonifying kidney and promoting blood circulation(shortened as Bushen Huoxue method)combined with cyclosporine plus androgen for the treatment of aplastic anemia(AA).Methods Randomized controlled trials(RCTs)of Bushen Huoxue method combined with cyclosporine plus androgen(trial group)versus cyclosporine plus androgen alone(control group)for the treatment of AA were retrieved from the major domestic and oversea databases,and then high-quality RCTs that met the inclusion criteria were screened.RevMan 5.3 software was used for meta-analysis.Results A total of 6 RCTs involving 365 patients were included.The results of meta-analysis showed that the total effective rate of AA in the trial group was significantly superior to that of the control group[OR=4.43,95%CI(2.50,7.84);P＜0.000 01].The trial group was superior to the control group on improving the peripheral blood indicators such as hemoglobin(HGB)level[MD=14.85,95%CI(10.66,19.05);P＜0.000 01],white blood cell(WBC)level[MD=0.61,95%CI(0.21,1.01);P=0.003],platelet(PLT)level[MD=16.51,95%CI(9.28,23.75);P＜0.000 01],and did not increase the incidence of adverse reactions such as hirsutism[OR=0.24,95%CI(0.10,0.61);P=0.003],acne[OR=0.30,95%CI(0.13,0.66);P=0.003],and abnormal liver function[OR=0.28,95%CI(0.09,0.83);P=0.02].Conclusion Bushen Huoxue method combined with cyclosporine plus androgen for the treatment of AA is superior to the use of cyclosporine plus androgen alone on enhancing clinical efficacy and improving the peripheral blood indicators,and has certain advantages in reducing the incidence of adverse reactions.
