Discussion on the Pathogenesis of Heavy Dampness Leading to Watery Diarrhea and the Modern Mechanism of Therapeutic Principle of Warming and Activating Spleen Yang
10.13359/j.cnki.gzxbtcm.2024.06.037
- VernacularTitle:"湿胜则濡泻"的病机内涵及其温运脾阳治则之现代机制探讨
- Author:
Kai ZHUANG
1
;
Feng-Ling ZHENG
;
Huan-Huan LUO
Author Information
1. 广州中医药大学基础医学院,广东广州 510006;广州中医药大学中医证候全国重点实验室,广东广州 510006
- Keywords:
heavy dampness leading to watery diarrhea;
spleen yang inactivation;
water-dampness retention and accumulation;
warming and activating spleen yang;
mitochondrial function;
diarrhea;
pathogenesis
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(6):1621-1627
- CountryChina
- Language:Chinese
-
Abstract:
The statement of heavy dampness leading to watery diarrhea was recorded in Huang Di Nei Jing(The Yellow Emperor's Inner Classic),which is not only an interpretation of the pathogenesis of diarrhea,but also one of the important principles to guide the clinical treatment of diarrhea in traditional Chinese medicine.The watery diarrhea can be caused by the invasion of external dampness,or results from the retention and accumulation of internal dampness.The combination of internal dampness and external dampness causes internal injury of spleen yang,and then the spleen yang is inactivated,which eventually results in diarrhea.Based on the pathogenesis of spleen yang inactivation and water-dampness retention and accumulation in heavy dampness leading to watery diarrhea,the therapeutic principle of warming and activating spleen yang should be performed.Modern Chinese medicine clinical practice and related mechanism research showed that the therapy of warming and activating spleen yang was closely related to the mitochondrial function in modern western medicine.The mechanism Linggui Zhugan Decoction and Fuzi Lizhong Decoction in relieving watery diarrhea by warming and activating spleen yang is related to the improvement of the energy metabolism disorder in the mitochondrion;the mechanism of Shengyang Yiwei Decoction and Shengyang Chushi Decoction in relieving watery diarrhea by raising yang and eliminating dampness is related to the improvement of mitochondrial damage in the inflammatory state;the mechanism of Xiao Jianzhong Decoction and Lizhong Decoction in relieving watery diarrhea by activating spleen is related to the improvement of mitochondrial oxidative damage.The exploration of the pathogenesis of heavy dampness leading to watery diarrhea and the modern mechanism of therapy of warming and activating spleen yang will provide reference for the study of the etiology and pathogenesis of pathogenic dampness and the dampness syndrome,and can provide reference for the prevention and treatment of diarrhea patients in the humid climate environment such as in Lingnan area and the middle and lower reaches of the Yangtze River and under the combined influence of improper dietary structure in modern society.
