Effect of Bugan Yishen Qianggu Formula on TGF-β1,tPINP,VEGF and Inflammatory Factors in Elderly Patients with Unstable Intertrochanteric Femur Fracture of Liver and Kidney Deficiency Type
10.13359/j.cnki.gzxbtcm.2024.06.013
- VernacularTitle:补肝益肾强骨方对老年不稳定性股骨粗隆间骨折肝肾亏虚型患者TGF-β1、tPINP、VEGF及炎性因子的影响
- Author:
Ke-Ying XIA
1
;
Shui-Hua XIE
Author Information
1. 江西中医药大学研究生院,江西南昌 330006
- Keywords:
Bugan Yishen Qianggu Formula;
elderly;
unstable intertrochanteric femur fracture;
liver and kidney deficiency type;
transforming growth factor β1(TGF-β1);
bone metabolism indicators;
inflammatory factors
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(6):1457-1464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of Bugan Yishen Qianggu Formula for the treatment of elderly patients with unstable intertrochanteric femur fractures of liver and kidney deficiency type.Methods A total of 138 elderly patients with unstable femoral intertrochanteric fracture of liver and kidney deficiency type were randomly divided into observation group and control group,with 69 cases in each group.The control group was treated with routine western medicine,and the observation group was treated with Bugan Yishen Qianggu Formula on the basis of treatment for the control group.The course of treatment for the two groups lasted for 12 weeks.Before and after treatment,the two groups were observed in the changes of Harris score,overall score of traditional Chinese medicine(TCM)symptoms,and serum levels of interleukin 6(IL-6),D-dimer(D-D),prostaglandin E2(PGE2),vascular endothelial growth factor(VEGF),transforming growth factor β1(TGF-β1),osteoprotegerin(OPG),total procollagen type 1 intact N-terminal propeptide(tPINP)and bone morphogenetic protein 2(BMP-2).The clinical efficacy,postoperative weight-bearing time and fracture healing time were compared between the two groups.Results(1)After 12 weeks of treatment,the total effective rate of the observation group was 94.20％(65/69)and that of the control group was 82.61％(57/69).The intergroup comparison showed that the efficacy of the observation group was significantly superior to that of the control group(x2=9.173,P＜0.05).(2)After treatment,the Harris scores in the two groups were increased(P＜0.05)and the total scores of TCM symptoms were decreased compared with those before treatment(P＜0.05),and the increase of the Harris scores and the decrease of the total scores of TCM symptoms in the observation group were superior to those in the control group(P＜0.05).(3)The fracture healing time and postoperative weight-bearing time of the observation group were significantly shorter than those of the control group,and the differences between the two groups were statistically significant(P＜0.05).(4)After treatment,the levels of serum IL-6,D-D and PGE2 in the two groups were lower(P＜0.05)and the levels of serum VEGF and TGF-β1 were higher than those before treatment(P＜0.05).The decrease of serum IL-6,D-D and PGE2 levels and the increase of serum VEGF and TGF-β1 levels in the observation group were significantly superior to those in the control group(P＜0.05).(5)After treatment,the levels of serum BMP-2,OPG and tPINP in the two groups were higher than those before treatment(P＜0.05),and the increase of serum BMP-2,OPG and tPINP levels in the observation group was significantly superior to that in the control group(P＜0.05).Conclusion For the treatment of elderly patients with unstable intertrochanteric femur fractures of liver and kidney deficiency type,the combined use of Bugan Yishen Qianggu Formula is beneficial to relieve the inflammatory response,regulate bone metabolism,and promote the improvement of hip joint function,thus to enhance the clinical efficacy.
