A propensity score matching study of Furong Ointment in the treatment of acute mastitis during lactation
10.3760/cma.j.cn115398-20231020-00183
- VernacularTitle:芙蓉膏治疗哺乳期急性乳腺炎的倾向性评分匹配研究
- Author:
Yuwei LI
1
;
Dongxiao ZHANG
Author Information
1. 首都医科大学附属北京中医医院乳腺科，北京 100010
- Keywords:
Mastitis;
lactation;
Acute disease;
Furong Oointment;
Propensity score matching (PSM);
Clinical efficacy
- From:
International Journal of Traditional Chinese Medicine
2024;46(11):1433-1438
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of Furong Ointment in the treatment of acute mastitis during lactation using propensity score matching.Methods:The medical records of 487 patients with acute mastitis during lactation were retrospectively analyzed in the Department of Mammography, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, from January 2019 to November 2022, and were divided into 404 cases in the Furong Ointment group and 83 cases in the control group according to whether or not Furong Ointment was used. The propensity score matching method was used to match and equalize the pre-treatment confounding factors in a 1:1 ratio, and finally 46 cases in each of the 2 groups were successfully matched. In the Furong Ointment group, Furong Ointment external application or Furong Ointment mammary gland patch was applied for 3 d, and the follow-up period was (6±2) d. In the control group, no medication was given during the observation period, and the observation period was 3 d. Observations were made to record the size of the mammary gland lumps and the extent of redness and swelling before and after the treatment in the patients of the two groups; the degree of mammary gland pain, breast milk smoothness, and breast tension were evaluated, and the quantitative grading scores of TCM symptoms were performed; the safety of the Furong Ointment was evaluated based on the results of the follow-up period.Results:The size of the lump [1 (1, 4) cm 2vs. 6 (2, 12) cm 2, 4 (2, 9) cm 2, Z=4.29] and the extent of redness and swelling [0 (0, 0) cm 2vs. 3 (1, 10) cm 2, 4 (0, 4) cm 2, Z=4.22] were reduced in the Furong Ointment group after treatment compared with those in the same group before treatment and the control group after observation ( P<0.05). The VAS score [1 (0, 3) vs. 2 (2, 4), Z=1.79], milk patency score [0 (0, 3) vs. 3 (0, 3), Z=3.05] and breast tension score [2 (0, 2) vs. 4 (2, 4), Z=2.77] in the Furong Ointment group were lower than those in the control group after observation ( P<0.05). After treatment, breast swelling and pain [0 (0, 0) vs. 1 (0, 2), 1 (0, 1), Z=1.12], breast lump area [2 (0, 2) vs. 3 (2, 3), 3 (2, 3), Z=1.44], breast skin burning [0 (0, 0) vs. 1 (0, 2), 1 (0, 1), Z=1.00], and the degree of headache/bodyache [0 (0,0) vs. 0 (0,1), 0 (0,1), Z=0.60], yellowish and greasy tongue coating [0 (0,0) vs. 0 (0,1), 0 (0,1), Z=0.69] score and total score [2 (3, 1) vs. 6 (5, 7), 5 (3, 5), Z=3.79] in the Furong Ointment group were reduced compared with those of the same group before the treatment and after the observation of the control group ( P<0.05). During the follow-up period, mass size score [0 (0, 2) vs.1 (1, 4), Z=2.73], breast tension score [0 (0, 2) vs. 2 (0, 2)] of the Furong Ointment group were lower than those in the control group ( P<0.05). No significant adverse drug reactions were observed in the Furong Ointment group during the observation period. Conclusion:Furong Ointment can effectively reduce the extent of breast lumps and redness in patients with acute mastitis during lactation, reduce the degree of breast pain, and improve the degree of breast milk patency and breast tension.
