Research progress on the molecular mechanism and related treatments of ferroptosis in osteosarcoma

VernacularTitle:铁死亡在骨肉瘤中的分子机制及相关治疗的研究进展
Author: Zihao WANG ¹ ; Yu WANG ; Xin YANG ; Yi HE ; Xingkui MO ; Tao YUAN
Author Information

1. 云南省肿瘤医院（昆明医科大学第三附属医院）骨科，昆明　650118
Keywords: Osteosarcoma; Ferroptosis; Reactive oxygen species; Antineoplastic protocols
From: Journal of International Oncology 2024;51(4):239-244
CountryChina
Language:Chinese
Abstract: Osteosarcoma is one of the most common primary malignant bone tumors, which has reached a "bottleneck" in the current clinical treatment of patients with osteosarcoma due to its poor prognosis and lack of therapeutic modalities. Recently, more and more researches have found that ferroptosis, as a novel cell death modality, may play an important role in osteosarcoma treatment. In recent years, with more in-depth studies on the mechanisms and molecular pathways related to ferroptosis, its specific therapeutic strategies in osteosarcoma have also been validated, which is expected to provide new ideas for the clinical treatment of osteosarcoma patients.