Predictive value of ultrasonography combined with serologic testing in the development of lymph node metastases in the neck in micropapillary thyroid carcinoma
10.3760/cma.j.cn115396-20240101-00001
- VernacularTitle:超声检查联合血清检测对甲状腺微小乳头状癌发生颈部淋巴结转移的预测价值
- Author:
Jian ZHANG
1
;
Dewei LI
Author Information
1. 山西医科大学第五临床医学院甲状腺外科，太原 030012
- Keywords:
Thyroid neoplasms;
Ultrasonography;
Genes;
Thyrotropin;
Lymphatic metastasis
- From:
International Journal of Surgery
2024;51(5):331-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective:By collecting and analyzing the clinical data of patients with micropapillary thyroid carcinoma, the ultrasound characteristics of the lesions and the mutation results of preoperative serum thyroid stimulating hormone (TSH) and BRAFV600 E genes, to investigate the high-risk factors of cervical lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC) and its predictive value. Methods:Retrospectivly analyzed the clinical data of 382 patients with PTMC confirmed by surgical pathology from January 2019 to September 2022 in the Fifth Clinical Medical College of Shanxi Medical University, including 142 male and 240 female, whose age was (43.24±11.27) years old, ranged from 16 to 67 years old. All patients were classified into cervical lymph node non-metastatic group ( n=195) and metastatic group ( n=187), according to postoperative pathology, unifactorial and multifactorial analyses were applied to analyze the risk factors for CLNM in patients with PTMC. Results:The differences between the 2 groups were statistically significant when comparing patients′ age, gender, serum TSH, tumor margins, morphology, microcalcifications, and maximum diameter of the tumor ( P<0.05), while all of the above factors were independent risk factors for CLNM in patients with PTMC( P<0.05). The risk of developing CLNM in the presence of microcalcifications was also 2.129 times higher than that in the absence of microcalcifications, so the presence of microcalcifications was a significant risk factor for the development of CLNM in PTMC ( P<0.05). Conclusion:Age, gender, routine ultrasound characteristics, and serum TSH have good predictive value for the development of cervical lymph node metastasis in patients with micropapillary thyroid carcinoma.
