Research progress in anti-tumor treatment strategies based on p53 protein
10.3760/cma.j.cn121382-20240822-00514
- VernacularTitle:基于p53蛋白的抗肿瘤治疗策略研究进展
- Author:
Han ZHANG
1
;
Wenfang LI
Author Information
1. 新疆大学药学院，新疆大学药物研究所，乌鲁木齐 830046
- Keywords:
p53 protein;
TP53 gene;
Mouse double minute 2;
Mouse double minute 4;
Anti-tumor;
Treatment strategy
- From:
International Journal of Biomedical Engineering
2024;47(5):504-512
- CountryChina
- Language:Chinese
-
Abstract:
The p53 protein is a key transcription factor and tumor suppressor, which activates in cellular stress response and prevents the cell malignant transformation by repairing or eliminating damaged cells. The p53 protein is mutated in more than 50% of malignant tumors, and is one of the proteins known to have the highest correlation with tumorigenesis and development. Restoring the tumor suppressor function of p53 protein has always been an important direction of anti-tumor research and development. In recent years, several anti-tumor treatment strategies based on p53 protein have entered the clinical trial stage and achieved promising efficacy. In this review, starting from the structure, function, and regulation of p53 protein, the research progress in anti-tumor treatment strategies based on p53 protein was summarized, including restoration of the function of mutp53 protein, degradation of mutp53 protein, targeting of the negative regulators of p53 protein, as well as immunotherapy and gene therapy based on p53 protein, with the aim of providing new innovative ideas for the subsequent researchers.
