Research progress in the role of bone morphogenetic protein family members for odontogenic differentiation
10.3760/cma.j.cn121382-20240603-00511
- VernacularTitle:骨形态发生蛋白家族成员在成牙分化中作用的研究进展
- Author:
Yun MO
1
;
Huiru ZOU
Author Information
1. 天津市口腔医院中心实验室，天津市口腔功能重建重点实验室，南开大学医学院口腔医学系，天津 300041
- Keywords:
Bone morphogenetic protein;
Odontogenic differentiation;
Dental defect;
Tooth regeneration
- From:
International Journal of Biomedical Engineering
2024;47(5):485-491
- CountryChina
- Language:Chinese
-
Abstract:
The bone morphogenetic protein (BMP) family has numerous members that play various regulatory roles in cell differentiation and tissue morphogenesis. They can precisely regulate cell proliferation, differentiation, apoptosis, and other processes. Notably, the members of the BMP family, such as BMP1, BMP2, BMP4, and BMP7, etc., play significant roles in the odontoblast differentiation. By delving into the expression and regulatory mechanisms of BMP during tooth development and reparative regeneration, a deeper understanding of the biological processes involved in tooth formation can be gained, providing theoretical support for the repair and regeneration of dental defects. However, the clinical application of BMP still faces numerous challenges, and how to precisely regulate the expression and activity of BMP during odontogenic differentiation remains to be further studied. In this review, the research progress in the role of the BMP family members for odontogenic differentiation was summarized, with a view to providing some reference for exploring new therapeutic strategies of BMP application in the repair and regeneration of dental defect.
