Research progress in remodeling immunosuppressive tumor microenvironment to enhance immunotherapy
10.3760/cma.j.cn121382-20240227-00412
- VernacularTitle:重塑免疫抑制肿瘤微环境增强免疫治疗的研究进展
- Author:
Hanyong WANG
1
;
Linhua ZHANG
;
Dunwan ZHU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Immunosuppression;
Tumor microenvironment;
Immunotherapy;
Combination therapy
- From:
International Journal of Biomedical Engineering
2024;47(4):388-394
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy, which utilizes the body’s own immune system to fight cancer, has become one of the mainstream clinical strategies for cancer treatment, and the number of immunotherapeutic drugs approved for clinical treatment has increased year by year. However, the tumor microenvironment with immunosuppressive ability significantly reduces the effect of immunotherapy, making immunotherapy suffer from low response rate, poor penetration, and other problems, and the clinical efficacy is not ideal. In this review paper, the methods and mechanisms of action of remodeling the immunosuppressive tumor microenvironment (ITME) by reducing immunosuppressive cells and soluble molecules were summarized, and the important role of combined chemotherapy, radiotherapy, and other therapeutic modalities was explored in remodeling the ITME and enhancing the efficacy of immunotherapy.
