Research progress of layered double hydroxide nanomaterials in treatment of cancer

VernacularTitle:层状双氢氧化物纳米材料在肿瘤治疗中的研究进展
Author: Xinyu YANG ¹ ; Linhua ZHANG ; Dunwan ZHU
Author Information

1. 中国医学科学院　北京协和医学院生物医学工程研究所，天津　300192
Keywords: Tumor microenvironment; Layered double hydroxides; Nanomaterial; Drug delivery; Immunotherapy
From: International Journal of Biomedical Engineering 2024;47(2):174-179
CountryChina
Language:Chinese
Abstract: Layered double hydroxides (LDHs) nanomaterial is a two-dimensional nanomaterial with a multi-layer structure. Due to their unique structural composition, LDHs can act as a "molecular switch" to achieve controllable release of payload under specific physiological pH conditions while remaining stable during blood circulation. In addition, LDHs are composed of several specific cations and have specific regulatory effects on various cellular functions. In addition to the excellent drug loading performance, LDHs can respond to the tumor microenvironment and realize a smart release of drugs, reduce the side effects of drugs, and enhance the tumor killing effect, having a wide range of applications in the field of tumor therapy. In this paper, the research progress of LDHs for chemotherapy drug delivery, immunotherapy, photodynamic therapy, and immunocombination therapy for tumors was reviewed.