Role of glymphatic system in cerebral small vascular disease
10.3760/cma.j.issn.1673-4165.2024.06.010
- VernacularTitle:胶质淋巴系统在脑小血管病中的作用
- Author:
Meng CAO
1
;
Xuemei CHEN
Author Information
1. 南京医科大学附属江宁医院神经内科，南京 211000
- Keywords:
Cerebral small vessel diseases;
Glymphatic system;
Aquaporin 4;
Magnetic resonance imaging;
Diffusion tensor imaging;
Cognition disorders
- From:
International Journal of Cerebrovascular Diseases
2024;32(6):455-459
- CountryChina
- Language:Chinese
-
Abstract:
The glymphatic system (GS) is a dynamic fluid transport and material clearance system based on aquaporin 4 on the astrocytic endfeet. It mainly includes the inflow pathway of cerebrospinal fluid in the periarterial space, the exchange pathway of cerebrospinal fluid and tissue fluid in the brain parenchyma, and the outflow pathway of cerebrospinal fluid in the perivenous space. The exact pathogenesis of cerebral small vessel disease (CSVD) is still unclear. There is currently a lack of effective means to intervene in its occurrence or progression. Existing studies suggest that CSVD and GS are closely related. This article elaborates on the role of GS in CSVD and looks forward to seeking new ideas for the treatment of CSVD.
