Levels and prognostic value of serum IL-17 and DKK-1 in patients with spinal fracture and spinal cord injury
10.3969/j.issn.1673-4130.2024.22.022
- VernacularTitle:脊柱骨折合并脊髓损伤患者血清IL-17、DKK-1水平及其预后价值
- Author:
Qiang HAO
1
;
Dandan SUN
Author Information
1. 大庆油田总医院骨科,黑龙江大庆 163000
- Keywords:
spinal fracture and spinal cord injury;
interleukin-17;
secretory protein Dickkopf-1;
prog-nosis
- From:
International Journal of Laboratory Medicine
2024;45(22):2800-2804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in serum levels of interleukin-17(IL-17)and secretory pro-tein Dickkopf-1(DKK-1)in patients with spinal fracture and spinal cord injury,and to explore their predictive value for poor prognosis.Methods A total of 133 patients with spinal fractures and spinal cord injury who un-derwent spinal canal decompression surgery at the hospital from October 2018 to August 2022 were regarded as the study group.According to the american spinal injury association(ASIA)neurological function level,they were separated into the good prognosis group(80 cases)and the poor prognosis group(53 cases).Anoth-er 128 patients with simple spinal fractures who underwent spinal canal decompression surgery in the hospital were collected as the control group.Clinical data of patients with spinal fractures and spinal cord injury were collected.Enzyme linked immunosorbent assay(ELISA)was applied to detect serum IL-17 and DKK-1 levels in all patients.Logistic regression was used to analyze factors influencing the prognosis of patients.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum IL-17 and DKK-1 levels for poor prognosis in patients.Results The serum levels of IL-17[(23.18±4.85)μg/mL vs.(12.97±3.91)pg/mL]and DKK-1[(2.48±0.41)ng/mL vs.(1.37±0.26)ng/mL]in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The serum IL-17[(26.61±4.85)pg/mL vs.(20.91±3.81)pg/mL]and DKK-1 levels[(2.83±0.48)ng/mL vs.(2.25±0.39)ng/mL]in the poor prognosis group were obviously higher than those in the good prognosis group,and the differences were statistically significant(P＜0.001).The independent risk factors for poor prognosis in patients included IL-17 and DKK-1(P＜0.05).The area under the curve(AUC)of serum IL-17,DKK-1 and their combined diagnosis for poor prognosis in patients was 0.822(95％CI:0.746-0.883),0.796(95％CI:0.718-0.861),and 0.910(95％CI:0.848-0.953),respectively.The diagnostic efficacy of the combination was higher than those of single detection(Z=2.034,P=0.042;Z=2.422,P=0.015).Conclusion Serum IL-17 and DKK-1 levels are elevated in patients with spinal fracture combined with spinal cord injury,and both have diagnostic value for the prognosis of the patients.
