Clinical significance of blood routine parameters in the diagnosis and management of patients with chronic heart failure
10.3969/j.issn.1673-4130.2024.22.021
- VernacularTitle:血常规相关参数在慢性心力衰竭患者诊疗中的临床价值研究
- Author:
Fei ZHANG
1
;
Yiqing ZHANG
;
Qi MU
Author Information
1. 东部战区总医院检验科,江苏南京 210002
- Keywords:
blood routine;
chronic heart failure;
heart function;
left ventricular ejection fraction
- From:
International Journal of Laboratory Medicine
2024;45(22):2795-2799,2804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between blood routine parameters and left ventricular e-jection fraction and cardiac function in patients with chronic heart failure(CHF),and to explore its clinical value in the assessment and prognosis prediction of CHF.Methods A total of 88 patients with CHF admitted to the Department of Cardiology in General Hospital of Eastern Theater Command from January to October in 2023 were selected as the research objects.Patients were divided into New York Heart Association(NYHA)Grade Ⅱ group(28 cases),NYHA Grade Ⅲ group(40 cases)and NYHA Grade Ⅳ group(20 cases)accord-ing to cardiac function.General data(age,gender,etc.),clinical data(medical and family history,main symp-toms and signs,medication,etc.),laboratory data[white blood cell count(WBC),neutrophil count(NEU),lymphocyte count(LYM),platelet count(PLT),mean platelet volume(MPV),platelet volume distribution width(PDW),red blood cell count(RBC),red blood cell distribution width(RDW),hematocrit(HCT),he-moglobin(Hb),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),etc.]and cardiac doppler ultrasound results were collected.The differences of blood routine parameters in patients with differ-ent cardiac function groups,and the correlation between routine blood parameters and left ventricular ejection fraction were analyzed retrospectively CHF patients were divided into heart failure with preserved left ventric-ular ejection fraction(HFpEF),heart failure with median left ventricular ejection fraction(HFmrEF),and heart failure with reduced left ventricular ejection fraction(HFrEF).Results RDW and NLR in the NYHA Grade Ⅲ group and NYHA Grade Ⅳ group were higher than those in the NYHA Grade Ⅱ group,and the differences were statistically significant(P＜0.05),RDW and NLR in the NYHA Grade Ⅳ group were higher than those in the NYHA Grade Ⅲ group,and the differences were statistically significant(P＜0.05).PDW and PLR in the NYHA Grade Ⅲ group and the NYHA Grade Ⅳ group were higher than those in the NYHA Grade Ⅱ group,and the differences were statistically significant(P＜0.05).MPV in the NYHA Grade Ⅳgroup was higher than that in the NYHA Grade Ⅱ group and the NYHA Grade m group,and the differences were statistically significant(P＜0.05).The levels of NEU,LYM and HCT in the NYHA Grade Ⅳ group were lower than those in the NYHA Grade Ⅱ group and the NYHA Grade Ⅲ group,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that RDW,PDW,MPV,PLR and NLR levels were negatively correlated with LVEF(all P＜0.05).With the decrease of left ventricular ejection fraction,the levels of RDW,PDW and NLR increased,and the levels of RDW,PDW and NLR in the HFmrEF group and the HFrEF group were lower than those in the HFpEF group,and the differences were statistically significant(P＜0.05).Conclusion The levels of RDW,NLR,PDW,MPV and PLR increase with the increase of cardiac functional grade,while the levels of NEU,LYM and HCT decreased with the increase of cardiac functional grade.RDW,PDW,MPV,NLR,PLR levels are negatively correlated with left ventricular ejection fraction in CHF patients,and the higher the level of related parameters,the worse the cardiac function of pa-tients.The above indicators may be used to evaluate the severity of CHF patients,and have certain clinical val-ue in evaluating the prognosis of patients.
