Correlation of serum PRL and IL-38 with type 2 diabetes mellitus combined with non-alcoholic fatty liver disease
10.3969/j.issn.1673-4130.2024.22.012
- VernacularTitle:血清PRL和IL-38与2型糖尿病合并非酒精性脂肪肝病的相关性分析
- Author:
Qiong FENG
1
;
Ling DANG
;
Meng JIANG
Author Information
1. 铜川市人民医院消化内科,陕西铜川 727100
- Keywords:
type 2 diabetes mellitus;
non-alcoholic fatty liver disease;
oxytocin;
interleukin-38
- From:
International Journal of Laboratory Medicine
2024;45(22):2747-2751,2757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum oxytocin(PRL)and interleukin-38(IL-38)with type 2 diabetes mellitus(T2DM)combined with non-alcoholic fatty liver disease(NAFLD).Methods A total of 172 patients with T2DM admitted to the Department of Gastroenterology in the hospital from January 2021 to January 2023 were selected as the T2DM group and were divided into the NAFLD group(88 cases)and the non-NAFLD group(84 cases)according to whether or not they were comorbid with NAFLD,and 67 physically examined healthy people during the same period were also selected as the control group.Serum PRL and IL-38 levels were measured by enzyme-linked immunosorbent assay.Logistic regression was used to ana-lyze the factors affecting T2DM combined with NAFLD,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum PRL and IL-38 for T2DM combined with NAFLD.Results Com-pared with the control group,serum PRL levels decreased and IL-38 levels increased in the T2DM group(P＜0.05).The NAFLD comorbidity rate was 51.16％(88/172)in 172 patients with T2DM.Compared with the non-NAFLD group,serum PRL levels decreased and IL-38 levels increased in the NAFLD group(P＜0.05).Increased body mass index,prolonged duration of T2DM,and elevated ghrelin aminotransferase,ghrelin amin-otransferase,total cholesterol,triacylglycerol,LDL cholesterol,and IL-38 were the independent risk factors for T2DM combined with NAFLD(P＜0.05),and elevated HDL cholesterol and PRL were the independent pro-tective factors(P＜0.05).The area under the curve for the combined prediction of serum PRL and IL-38 for T2DM combined with NAFLD was 0.897,which was greater than 0.779 and 0.782 of serum PRL and IL-38 alone(P＜0.05).Conclusion Reduced serum PRL levels and increased IL-38 levels in T2DM patients are in-dependent influencing factors for T2DM combined with NAFLD,and the combination of serum PRL and IL-38 has a high predictive value for T2DM combined with NAFLD.
