Progress on ARID1A gene mutation and cisplatin resistance in gastric cancer
10.3969/j.issn.1673-4130.2024.21.020
- VernacularTitle:ARID1A基因突变与胃癌顺铂耐药的研究进展
- Author:
Zhenlu ZHENG
1
;
Xiaoling GAO
Author Information
1. 甘肃中医药大学公共卫生学院,甘肃兰州 730000
- Keywords:
gastric cancer;
AT-rich interactive domain 1A gene;
DNA damage repair;
metabolic re-modeling;
chemoresistance
- From:
International Journal of Laboratory Medicine
2024;45(21):2662-2667,2674
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer has high mortality and case fatality rate worldwide,especially in East Asia.Che-moresistance or chemotherapeutic resistance remains an important issue affecting the prognosis of gastric cancer patients.Mutations in the AT-rich interactive domain 1A(ARID1A)gene,an important member of the chromatin remodeling complex,are common in gastric cancer and are closely related to the clinical manifesta-tions of patients as well as the response to chemotherapy.Deletion or mutation of the ARID1A gene may lead to increased resistance of gastric cancer cells to platinum-based chemotherapeutic agents.In this paper,the bi-ological role of ARID1A gene,the alteration of DNA damage repair and metabolic remodeling in cisplatin re-sistance,and the possible mechanism of ARID1A gene involved in chemoresistance in gastric cancer are re-viewed.
